PLPP1 Gene Summary [Human]
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | PLPP1 |
| Official Name | phospholipid phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:9228] |
| Ensembl ID | ENSG00000067113 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 1 |
| Synonyms | Hic53, Hpic53, LLP1a, LPP-1, mPAP, PAP2, PAP-2a, PAP2-alpha, PAP2-α, Phosphatidic acid phosphatase, Phosphatidic acid phosphatase 2a, phospholipid phosphatase 1, PPAP2A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLPP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- diacylglycerol pyrophosphate phosphatase
- lipid phosphatase
- PAP2 superfamily
- sphingosine-1-phosphate phosphatase
- phosphatidate phosphatase
- phosphatase
- protein binding
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast adenocarcinoma
- serous ovarian adenocarcinoma
- diabetes mellitus
- serous ovarian cancer
- uterine leiomyoma
- leiomyomatosis
- insulin-dependent diabetes mellitus
- plasma cell neoplasm
- B cell cancer
- mature B-cell neoplasia
role in cell
- quantity
- survival
- activation
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Nucleus
- apical membrane
- caveolae
- alpha granules
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLPP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- intracellular steroid hormone receptor signaling pathway
- sphingosine metabolic process
- signal transduction
- negative regulation of cell proliferation
- ceramide metabolic process
- androgen receptor signaling pathway
- protein kinase C-activating G-protein coupled receptor signaling pathway
- regulation of lipid metabolic process
- phospholipid metabolic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- caveola
- extracellular vesicular exosome
- membrane
- membrane raft
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- protein binding
- lysophosphatidic acid phosphatase activity
- sphingosine-1-phosphate phosphatase activity
- diacylglycerol diphosphate phosphatase activity
- lipid phosphatase activity