VGF Gene Summary [Human]
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | VGF |
| Official Name | VGF nerve growth factor inducible [Source:HGNC Symbol;Acc:HGNC:12684] |
| Ensembl ID | ENSG00000128564 |
| Bio databases IDs | |
| Aliases | VGF nerve growth factor inducible, neuro-endocrine specific protein VGF |
| Synonyms | Gm1052, LOC100909521, SCG7, SgVII, Vgf8a, VGF nerve growth factor inducible |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VGF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neuropeptide hormone
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- depressive disorder
- breast cancer
- organismal death
- weight gain
- bipolar disorder
- obesity
- first-onset paranoid schizophrenia
- hyperactive behavior
- survival
role in cell
- expression in
- cell viability
- growth
- phosphorylation in
- survival
- quantity
- differentiation
- size
- migration
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- intracellular membrane-bounded organelle
- perinuclear region
- Golgi Apparatus
- endoplasmic reticulum lumen
- synaptic vesicles
- synapse
- cytoplasmic vesicles
- secretory vesicles
- secretory granules
- membrane processes
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VGF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- insulin secretion
- signal transduction
- response to cAMP
- response to dietary excess
- defense response to bacterium
- ovarian follicle development
- response to cold
- response to insulin stimulus
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- glucose homeostasis
- carbohydrate homeostasis
- sexual reproduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- Golgi apparatus
- neuronal cell body
- transport vesicle
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- neuropeptide hormone activity
- hormone activity