CSNK1D Gene Summary [Human]

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Details

Type
Nonsense Mediated Decay
Official Symbol
CSNK1D
Official Name
casein kinase 1 delta [Source:HGNC Symbol;Acc:HGNC:2452]
Ensembl ID
ENSG00000141551
Bio databases IDs NCBI: 1453 Ensembl: ENSG00000141551
Aliases casein kinase 1 delta
Synonyms 1200006A05Rik, ASPS, casein kinase 1 delta, casein kinase 1, delta, casein kinase 1 δ, casein kinase 1, δ, Ck1 delta, Ck1 δ, CKId, CKI-delta, CKI-δ, D930010H05RIK, FASPS2, HCKID
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSNK1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein serine/threonine kinase
  • Protein kinase (unclassified specificity)
  • protein kinase
  • catalytic domain
  • Protein tyrosine and serine/threonine kinase
  • centrosomal localization signal
  • protein binding
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • kinase domain
  • Tau-protein kinase
  • Protein Kinases, catalytic domain
  • SQIP motif
  • alcohol group acceptor phosphotransferase
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • familial advanced sleep phase syndrome type 2
regulated by
  • etoposide
  • TP53
  • Caco2 cells
  • PSME3
  • thioacetamide
  • camptothecin
  • prednisolone
  • hydroxyurea
  • nocodazole
  • SETD2
role in cell
  • binding in
  • proliferation
  • expression in
  • phosphorylation in
  • accumulation in
  • growth
  • binding
  • nucleation
  • outgrowth
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • spindle apparatus
  • cilia
  • perinuclear region
  • cellular membrane
  • actin cytoskeleton
  • Nucleus
  • Plasma Membrane
  • basal bodies
  • centrosome
  • Golgi Apparatus
  • cytosol
  • nucleoplasm
  • spindle fibers
  • neurites
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CSNK1D gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction
  • protein localization in Golgi apparatus
  • Golgi organization
  • positive regulation of non-canonical Wnt receptor signaling pathway
  • microtubule nucleation
  • positive regulation of canonical Wnt receptor signaling pathway
  • protein phosphorylation
  • regulation of circadian rhythm
  • endocytosis
  • COPII vesicle coating
  • spindle assembly
  • circadian regulation of gene expression
  • positive regulation of protein phosphorylation
  • Wnt receptor signaling pathway
  • peptidyl-serine phosphorylation
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  • protein localization to centrosome

Cellular Component

Where in the cell the gene product is active
  • cilium basal body
  • Golgi apparatus
  • plasma membrane
  • nucleoplasm
  • spindle microtubule
  • nucleus
  • centrosome
  • perinuclear region of cytoplasm
  • cytoplasm
  • spindle
  • cytosol
  • endoplasmic reticulum-Golgi intermediate compartment membrane

Molecular Function

What the gene product does at the molecular level
  • tau-protein kinase activity
  • ATP binding
  • protein binding
  • cadherin binding
  • protein kinase activity
  • protein serine/threonine kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.