PLPP2 Gene Summary [Human]
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PLPP2 |
| Official Name | phospholipid phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:9230] |
| Ensembl ID | ENSG00000141934 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 2 |
| Synonyms | LPP2, PAP-2c, PAP2-G, PAP2-gamma, PAP2-γ, phospholipid phosphatase 2, PPAP2C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLPP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- lipid phosphatase
- PAP2 superfamily
- sphingosine-1-phosphate phosphatase
- phosphatidate phosphatase
- phosphatase
- protein binding
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
regulates
- ERK1/2
- ceramide
- sphingosine-1-phosphate
- phospholipid
- cyclin A
- lysophosphatidic acid
- D-sphingosine
- phosphatidic acid
- sphingolipid
role in cell
- proliferation
- S phase
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
- caveolae
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLPP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- sphingosine metabolic process
- signal transduction
- ceramide metabolic process
- phospholipid metabolic process
- sphingolipid catabolic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endoplasmic reticulum membrane
- early endosome
- caveola
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- protein binding
- sphingosine-1-phosphate phosphatase activity