Inpp5a Gene Summary [Mouse]
Enables inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway. Located in dendrite. Is expressed in several structures, including alimentary system; craniocervical region bone; limb; nervous system; and sensory organ. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Inpp5a |
| Official Name | inositol polyphosphate-5-phosphatase A [Source:MGI Symbol;Acc:MGI:2686961] |
| Ensembl ID | ENSMUSG00000025477 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-5-phosphatase A |
| Synonyms | 5PTASE, inositol polyphosphate-5-phosphatase A, LOC100910988, nk6, PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE type I, type I INS(1,4,5)P3 5-PHOSPHATASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- inositol-polyphosphate 5-phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- phosphatase
- protein binding
- phosphoinositide phosphatase
- PH-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- oligodendroglioma
- hypertension
- liver cancer
- polycystic ovary syndrome
- liver cirrhosis
- glioblastoma
- glioblastoma cancer
- insomnia
- ulcerative colitis
role in cell
- quantity
- survival
- cell death
- assembly
- exocytosis
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- cellular membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
- inositol phosphate metabolic process
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- inositol-1,4,5-trisphosphate 5-phosphatase activity
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
- PH domain binding
- inositol-polyphosphate 5-phosphatase activity