TMEM260 Gene Summary [Human]

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
TMEM260
Official Name
transmembrane protein 260 [Source:HGNC Symbol;Acc:HGNC:20185]
Ensembl ID
ENSG00000070269
Bio databases IDs NCBI: 54916 Ensembl: ENSG00000070269
Aliases transmembrane protein 260
Synonyms 5930435P15, 6720456H20Rik, C14orf101, LOC686366, RGD1562018, SHDRA, transmembrane protein 260
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM260 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Protein of unknown function (DUF2723)
  • enzyme
  • dolichyl-phosphate-mannose-protein mannosyltransferase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • structural heart defects and renal anomalies syndrome
  • acute myeloid leukemia
regulated by
  • ETV6-RUNX1
  • valproic acid
regulates
role in cell
  • growth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • Endoplasmic Reticulum
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TMEM260 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein maturation
  • protein O-linked mannosylation

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane

Molecular Function

What the gene product does at the molecular level
  • dolichyl-phosphate-mannose-protein mannosyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.