CD96 Gene Summary [Human]

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Details

Type
Protein Coding
Official Symbol
CD96
Official Name
CD96 molecule [Source:HGNC Symbol;Acc:HGNC:16892]
Ensembl ID
ENSG00000153283
Bio databases IDs NCBI: 10225 Ensembl: ENSG00000153283
Aliases CD96 molecule
Synonyms 1700109I12RIK, CD96 antigen, CD96 molecule, TACTILE
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD96 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • immunoglobulin domain
  • immunoglobulin G-like domain
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • idiopathic scoliosis
  • survival
  • insulin-dependent diabetes mellitus
  • psoriasis like inflammation
  • C syndrome
  • proliferative diabetic retinopathy
  • dementia
regulated by
  • HRAS
  • Francisella tularensis subsp. holarctica LVS
  • T lymphocytes
  • IL15
  • natural T-regulatory cells
  • PVR
  • SATB2
  • mir-34 (includes others)
  • KLRK1
  • IL18
regulates
role in cell
  • expression in
  • adhesion
  • function
  • cytotoxicity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cell surface
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human CD96 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell-matrix adhesion
  • inflammatory response
  • immune response
  • negative regulation of natural killer cell cytokine production
  • cell adhesion
  • response to lipopolysaccharide
  • negative regulation of interferon-gamma production

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

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