PLXNB2 Gene Summary [Human]
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | PLXNB2 |
| Official Name | plexin B2 [Source:HGNC Symbol;Acc:HGNC:9104] |
| Ensembl ID | ENSG00000196576 |
| Bio databases IDs | |
| Aliases | plexin B2 |
| Synonyms | AI841137, Debt, dJ402G11.3, lncFAL, MM1, Nbla00445, NM-4, PLEXB2, Plexin B2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLXNB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- cytoplasmic domain
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- PDZ binding motif
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the PLXNB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- hypertension
- colorectal cancer
- biliary tract cancer
- cutaneous melanoma
- epithelial cancer
- epithelial neoplasia
- cancer
- COVID-19
- skin cancer
role in cell
- expression in
- proliferation
- apoptosis
- activation
- migration
- assembly
- formation
- abnormal morphology
- adhesion
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cell surface
- Extracellular Space
- cellular membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLXNB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of translation
- negative regulation of cell adhesion
- brain development
- homophilic cell adhesion
- neuroblast proliferation
- positive regulation of axonogenesis
- neural tube closure
- regulation of protein phosphorylation
- regulation of GTPase activity
- positive regulation of neuron projection development
- regulation of cell migration
- regulation of neuron migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- extracellular vesicular exosome
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- semaphorin receptor activity