AFM Gene Summary [Human]
This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AFM |
| Official Name | afamin [Source:HGNC Symbol;Acc:HGNC:316] |
| Ensembl ID | ENSG00000079557 |
| Bio databases IDs | |
| Aliases | afamin |
| Synonyms | AFAMIN, AFAMIN precursor, ALB2, ALBA, ALF, alpha-Alb, α-Alb |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AFM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ALBUMIN
- tocopherol binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- Alzheimer disease
- prostate cancer
- diabetic nephropathy
- prostatic carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- ovarian cancer
regulates
- AKT
- vitamin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AFM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport within extracellular region
- protein stabilization
- vitamin transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- vitamin E binding