Afm Gene Summary [Mouse]
Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Predicted to be located in extracellular space. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; liver; and metanephros. Orthologous to human AFM (afamin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Afm |
| Official Name | afamin [Source:MGI Symbol;Acc:MGI:2429409] |
| Ensembl ID | ENSMUSG00000029369 |
| Bio databases IDs | |
| Aliases | afamin |
| Synonyms | AFAMIN, AFAMIN precursor, ALB2, ALBA, ALF, alpha-Alb, α-Alb |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Afm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ALBUMIN
- tocopherol binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- Alzheimer disease
- prostate cancer
- diabetic nephropathy
- prostatic carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- ovarian cancer
regulates
- AKT
- vitamin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Afm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport within extracellular region
- protein stabilization
- vitamin transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- vitamin E binding