GBP1 Gene Summary [Human]
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | GBP1 |
| Official Name | guanylate binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4182] |
| Ensembl ID | ENSG00000117228 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 1 |
| Synonyms | GBP, Gbp1-ps1, GBPI, guanylate binding protein 1, guanylate binding protein 1, pseudogene 1, hGBP1, IFI67-K, RGD1560801 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanosine-diphosphatase
- cytokine binding
- heat shock protein binding
- small monomeric GTPase
- GTPase
- helical domain
- spectrin binding
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- lipopolysaccharide binding
- Guanylate-binding protein, C-terminal domain
- GTP binding
- GTPase domain
- Guanylate-binding protein, N-terminal domain
- GDP binding
- actin binding
- ClassIIa_HDAC_Gln-rich-N
- protein homodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- diabetes mellitus
- systemic lupus erythematosus
- systemic sclerosis
- epithelial cancer
- dermatomyositis
- rheumatoid arthritis
- glioblastoma
- tuberculosis
role in cell
- apoptosis
- expression in
- activation in
- replication in
- proliferation
- alternative splicing in
- cellular infiltration by
- cell viability
- migration
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- Golgi Apparatus
- cytosol
- vesicle membrane
- cytoplasmic vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of substrate adhesion-dependent cell spreading
- defense response to bacterium
- defense response to protozoan
- negative regulation of T cell receptor signaling pathway
- negative regulation of interleukin-2 production
- innate immune response
- negative regulation of ERK1 and ERK2 cascade
- cellular response to interleukin-1
- defense response to virus
- regulation of calcium-mediated signaling
- cellular response to tumor necrosis factor
- cellular response to interferon-gamma
- protein localization to vacuole
- cytolysis in other organism
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- cytoplasm
- vesicle membrane
- actin cytoskeleton
- cytosol
- cytoplasmic vesicle
- Golgi membrane
- Golgi apparatus
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- guanosine-diphosphatase activity
- lipopolysaccharide binding
- GTP binding
- protein binding
- actin binding
- spectrin binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding
- Hsp90 protein binding
- cytokine binding
- enzyme binding