CCT3 Gene Summary [Human]
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | CCT3 |
| Official Name | chaperonin containing TCP1 subunit 3 [Source:HGNC Symbol;Acc:HGNC:1616] |
| Ensembl ID | ENSG00000163468 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 3 |
| Synonyms | Cct1 γ, CCTG, CCT-gamma, CCT-γ, chaperonin containing TCP1 subunit 3, Chaperonin subunit 3 (gamma), Chaperonin subunit 3 (γ), Matricin, NEDSVH, PIG48, TCP-1-gamma, Tcp1-rs3, TCP-1-γ, TRIC5, TriC-P5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Alzheimer disease
- non-small cell lung cancer
- organismal death
- Parkinson disease
- heart failure
- bladder cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- Burkitt lymphoma
role in cell
- cell death
- apoptosis
- expression in
- growth
- proliferation
- migration
- invasion by
- accumulation in
- transport in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- cytoskeleton
- cilia
- Nucleus
- microtubules
- cytosol
- nucleoli
- perikaryon
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- cytoskeleton
- extracellular vesicular exosome
- cell body
- cytosol
- sperm protein complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- protein binding involved in protein folding
- RNA binding
- unfolded protein binding