IGSF9 Gene Summary [Human]
Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within dendrite development and regulation of synapse organization. Predicted to be located in dendrite and inhibitory synapse. Predicted to be integral component of membrane. Predicted to be active in axon and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | IGSF9 |
| Official Name | immunoglobulin superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:18132] |
| Ensembl ID | ENSG00000085552 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily member 9, turtle (Drosophila) homolog A |
| Synonyms | 644ETD8, Dasm1, FP18798, IGSF9A, immunoglobulin superfamily member 9, immunoglobulin superfamily, member 9, Kiaa1355-hp, mKIAA1355, Ncaml, NRT1, RGD:1304566 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGSF9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- PDZ binding motif
- proline rich domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- diabetic nephropathy
- desmoplastic small round cell tumor
- soft tissue sarcoma cancer
- metastasis
- behavioral deficit
- organismal death
- seizures
- colon cancer
- yolk sac neoplasm
role in cell
- migration
- formation
- growth
- invasion by
- abnormal morphology
- organization
- maturation
- development
- adhesion
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- synaptic membrane
- synapse
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGSF9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse organization
- dendrite self-avoidance
- axon guidance
- homophilic cell adhesion
- dendrite development
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- dendrite
- axon
- plasma membrane