CDC42BPB Gene Summary [Human]
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC42BPB |
| Official Name | CDC42 binding protein kinase beta [Source:HGNC Symbol;Acc:HGNC:1738] |
| Ensembl ID | ENSG00000198752 |
| Bio databases IDs | |
| Aliases | CDC42 binding protein kinase beta |
| Synonyms | CDC42 binding protein kinase beta, CDC42 binding protein kinase β, CDC42BP beta, CDC42BP β, CHOCNS, MRCKB, Mrck beta, Mrck β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC42BPB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- Synaptonemal complex protein 1 (SCP-1)
- ATP binding
- KELK-motif containing domain of MRCK Ser/Thr protein kinase
- Protein kinase domain
- Laminin Domain I
- Tropomyosin
- Myosin-like coiled-coil protein
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- Tyrosine kinase, catalytic domain
- Mitotic checkpoint protein
- Protein kinase (unclassified specificity)
- Hyaluronan mediated motility receptor N-terminal
- Protein tyrosine and serine/threonine kinase
- CNH domain
- enzyme binding
- protein binding
- DMPK coiled coil domain like
- Pleckstrin homology-like domain
- magnesium ion binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- kinase
- Serine/Threonine protein kinases, catalytic domain
- RIM-binding protein of the cytomatrix active zone
- binding protein
- Protein Kinases, catalytic domain
- self-activated kinase domain
- Trichohyalin-plectin-homology domain
- Septation ring formation regulator, EzrA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- Parkinson disease
- Chilton-Okur-Chung neurodevelopmental syndrome
- hereditary disorder
- mature B-cell neoplasia
- pervasive developmental disorder
- neurodevelopmental disorder
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
role in cell
- expression in
- growth
- formation
- replication in
- invasiveness
- rearrangement
- rearrangement in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- actin cytoskeleton
- intercellular junctions
- cytosol
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC42BPB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- signal transduction
- actomyosin structure organization
- establishment or maintenance of cell polarity
- protein phosphorylation
- cell migration
- actin cytoskeleton organization
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
- cell leading edge
- cytosol
- actomyosin
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- small GTPase binding
- protein kinase activity
- protein serine/threonine kinase activity