Igsf9 Gene Summary [Mouse]
Enables cell-cell adhesion mediator activity. Acts upstream of or within dendrite development; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of synapse organization. Located in axon; dendrite; and inhibitory synapse. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Orthologous to human IGSF9 (immunoglobulin superfamily member 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igsf9 |
| Official Name | immunoglobulin superfamily, member 9 [Source:MGI Symbol;Acc:MGI:2135283] |
| Ensembl ID | ENSMUSG00000037995 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily, member 9 |
| Synonyms | 644ETD8, Dasm1, FP18798, IGSF9A, immunoglobulin superfamily member 9, immunoglobulin superfamily, member 9, Kiaa1355-hp, mKIAA1355, Ncaml, NRT1, RGD:1304566 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igsf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- immunoglobulin domain
- cell adhesion molecule binding
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- PDZ binding motif
- proline rich domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- diabetic nephropathy
- desmoplastic small round cell tumor
- soft tissue sarcoma cancer
- metastasis
- behavioral deficit
- organismal death
- seizures
- colon cancer
- yolk sac neoplasm
role in cell
- migration
- formation
- growth
- invasion by
- abnormal morphology
- organization
- maturation
- development
- adhesion
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- synaptic membrane
- synapse
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igsf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse organization
- dendrite self-avoidance
- axon guidance
- homophilic cell adhesion
- dendrite development
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- dendrite
- axon
- plasma membrane