FMNL2 Gene Summary [Human]
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FMNL2 |
| Official Name | formin like 2 [Source:HGNC Symbol;Acc:HGNC:18267] |
| Ensembl ID | ENSG00000157827 |
| Bio databases IDs | |
| Aliases | formin like 2 |
| Synonyms | 5430425K04RIK, FHOD2, formin-like 2, Man, RGD1560248 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FMNL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- Diaphanous FH3 Domain
- Uncharacterized protein conserved in bacteria (DUF2312)
- Rho-binding domain
- formin homology domain 3
- Diaphanous GTPase-binding Domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- glaucoma
- asthma
- open-angle glaucoma
- Barrett syndrome
- pervasive developmental disorder
- astigmatism
- corneal astigmatism
- Moyamoya disease
regulates
- fascin
- actin
role in cell
- migration
- morphogenesis
- organization
- frequency
- formation in
- myofibrillogenesis in
- polymerization in
- assembly in
- repair
- ultrastructure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- glutaminergic synapse
- postsynaptic region
- sarcomere
- cytosol
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FMNL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- regulation of cell shape
- cytoskeleton organization
- regulation of cell morphogenesis
- cell migration
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- cadherin binding
- small GTPase binding