SLC40A1 Gene Summary [Human]
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC40A1 |
| Official Name | solute carrier family 40 member 1 [Source:HGNC Symbol;Acc:HGNC:10909] |
| Ensembl ID | ENSG00000138449 |
| Bio databases IDs | |
| Aliases | solute carrier family 40 member 1, ferroportin 1 |
| Synonyms | Car1, Dusg, FP1, FPN, FPN1, Fpt, HFE4, IREG1, MST079, MSTP079, MTP, MTP1, NEWGENE 620180, Ol5, PCM, SLC11A3, Slc39a1, solute carrier family 40 (iron-regulated transporter), member 1, solute carrier family 40 member 1, Zip1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC40A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron transporter
- Ferroportin1 (FPN1)
- ubiquitination site
- Major Facilitator Superfamily
- iron ion transporter
- protein binding
- identical protein binding
- polypeptide hormone binding
- transporter
- phosphorylation site
Pathways
Biological processes and signaling networks where the SLC40A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial neoplasia
- epithelial cancer
- cancer
- breast cancer
- breast carcinoma
- high-grade serous ovarian cancer
- breast or ovarian cancer
- urogenital cancer
role in cell
- cell death
- expression in
- cell viability
- apoptosis
- mitochondrial respiration in
- degradation in
- accumulation in
- quantity
- production in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- basolateral cell surfaces
- basolateral membrane
- nucleoplasm
- nodes of Ranvier
- synaptic vesicles
- Schmidt-Lanterman incisures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC40A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- multicellular organismal iron ion homeostasis
- negative regulation of apoptotic process
- apoptotic process
- lymphocyte homeostasis
- transcription from RNA polymerase II promoter
- establishment of localization in cell
- spleen trabecula formation
- positive regulation of transcription from RNA polymerase II promoter
- iron ion transmembrane transport
- endothelium development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- synaptic vesicle
- membrane
- cytosol
- basolateral plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- iron ion transmembrane transporter activity
- metal ion binding
- peptide hormone binding
- ferrous iron transmembrane transporter activity