PPEF1 Gene Summary [Human]
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PPEF1 |
| Official Name | protein phosphatase with EF-hand domain 1 [Source:HGNC Symbol;Acc:HGNC:9243] |
| Ensembl ID | ENSG00000086717 |
| Bio databases IDs | |
| Aliases | protein phosphatase with EF-hand domain 1, protein phosphatase 7, catalytic subunit, alpha isozyme |
| Synonyms | LOC100363004, PP7, PPEF, PPP7C, PPP7CA, protein phosphatase with EF hand calcium-binding domain 1, protein phosphatase with EF-hand domain 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPEF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- EF-hand domain pair
- EFh
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- Calcineurin-like phosphoesterase
- IQ calmodulin-binding motif
- Calmodulin-binding motif
- EF-hand domain
- EF hand
- IQ domain
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPEF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of stimulus involved in sensory perception
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- iron ion binding
- calcium ion binding
- manganese ion binding
- myosin phosphatase activity