PPP1R9B Gene Summary [Human]
This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R9B |
| Official Name | protein phosphatase 1 regulatory subunit 9B [Source:HGNC Symbol;Acc:HGNC:9298] |
| Ensembl ID | ENSG00000108819 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 9B, spinophilin, Neurabin-2 |
| Synonyms | NEB2, Neurabin2, PPP1R6, PPP1R9, protein phosphatase 1 regulatory subunit 9B, protein phosphatase 1, regulatory subunit 9B, SPINO, Spinophilin, SPL, Spn |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R9B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase
- nucleic acid binding
- G-protein-coupled receptor binding
- canonical PDZ domain
- PP1 binding domain
- coiled-coil domain
- enzyme
- protein binding
- PDZ domain
- actin filament binding
- protein phosphatase inhibitor activity
- kinase binding
- protein phosphatase 1 binding
- binding protein
- immunoreceptor tyrosine-based inhibition motif
- actin binding
- ion channel binding
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- mood disorder
- obesity
- inflammatory pain
- seizures
role in cell
- binding in
- apoptosis
- growth
- migration
- colony formation
- function
- association
- cell cycle progression
- cell death
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- cortical actin cytoskeleton
- organelle
- intracellular space
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- Mitochondria
- cytoplasmic face of plasma membrane
- membrane ruffles
- lateral plasma membrane
- nucleoplasm
- dendritic spines
- dendritic spine neck
- dendritic spine head
- growth cone
- filopodia
- perikaryon
- dendrites
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R9B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- response to prostaglandin E stimulus
- regulation of exit from mitosis
- actin filament organization
- learning
- developmental process involved in reproduction
- cellular response to estradiol stimulus
- negative regulation of cell growth
- cellular response to morphine
- regulation of cell cycle
- calcium-mediated signaling
- cell migration
- regulation of opioid receptor signaling pathway
- dendrite development
- male mating behavior
- neuron projection development
- actin filament depolymerization
- hippocampus development
- response to nicotine
- response to steroid hormone stimulus
- cerebral cortex development
- regulation of cell growth by extracellular stimulus
- filopodium assembly
- regulation of cell proliferation
- response to amphetamine
- regulation of protein phosphorylation
- cellular response to epidermal growth factor stimulus
- cellular response to xenobiotic stimulus
- response to immobilization stress
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neuronal cell body
- dendritic spine neck
- plasma membrane
- nucleoplasm
- dendritic spine head
- growth cone
- dendrite
- adherens junction
- protein phosphatase type 1 complex
- cytoplasm
- actin cytoskeleton
- ruffle membrane
- filopodium
- cortical actin cytoskeleton
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein phosphatase inhibitor activity
- protein binding
- D2 dopamine receptor binding
- protein kinase activity
- protein phosphatase 1 binding
- ion channel binding
- kinase binding