DLST Gene Summary [Human]
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DLST |
| Official Name | dihydrolipoamide S-succinyltransferase [Source:HGNC Symbol;Acc:HGNC:2911] |
| Ensembl ID | ENSG00000119689 |
| Bio databases IDs | |
| Aliases | dihydrolipoamide S-succinyltransferase, Dihydrolipoyllysine-residue succinyltransferase, 2-oxoglutarate dehydrogenase complex component E2 |
| Synonyms | 1600017E01Rik, 4632413C10Rik, 4930529O08Rik, dihydrolipoamide S-succinyltransferase, DLTS, E2K, Kdh E2, KGD2, ODO2, PGL7, PPGL7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Biotinyl_lipoyl_domains
- dihydrolipoamide S-succinyltransferase
- sucB
- pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
- heat shock protein binding
- 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
- Biotin-requiring enzyme
- enzyme
- protein binding
- chaperone binding
- transferase, transferring acyl groups
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- non-small cell lung carcinoma
- migraines
- Alzheimer disease
- hereditary paraganglioma-pheochromocytoma syndrome
- paraganglioma formation
- hereditary cancer-predisposing syndrome
- familial neoplasia
role in cell
- expression in
- growth
- cell death
- proliferation
- mitochondrial respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DLST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- tricarboxylic acid cycle
- 2-oxoglutarate metabolic process
- succinyl-CoA metabolic process
- L-lysine catabolic process to acetyl-CoA via saccharopine
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- oxoglutarate dehydrogenase complex
- mitochondrion
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- dihydrolipoyllysine-residue succinyltransferase activity
- transferase activity, transferring acyl groups
- protein binding