UBR5 Gene Summary [Human]
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | UBR5 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 5 [Source:HGNC Symbol;Acc:HGNC:16806] |
| Ensembl ID | ENSG00000104517 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 5 |
| Synonyms | DD5, EDD, EDD1, HYD, LOC102551120, Rat100, ubiquitin protein ligase E3 component n-recognin 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBR5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- UBA domain-like superfamily
- LXXLL motif
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- ubiquitin binding
- central domain
- protein domain specific binding
- enzyme
- protein binding
- Poly-adenylate binding protein, unique domain
- C-terminal domain of Poly(A)-binding protein
- Putative zinc finger in N-recognin
- HECTc
- UBR-box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioma formation
- gastroesophageal reflux
- glioma
- insomnia
- Hutchinson-Gilford progeria syndrome
- gastric carcinoma
- gastric epithelial cancer
- postmenopausal osteoporosis
- infection by Influenza A virus subtype H1N1
role in cell
- proliferation
- activation in
- phosphorylation in
- expression in
- cell viability
- growth
- invasion by
- apoptosis
- migration
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pH resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBR5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein K11-linked ubiquitination
- positive regulation of protein import into nucleus
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein polyubiquitination
- positive regulation of canonical Wnt receptor signaling pathway
- response to DNA damage stimulus
- negative regulation of smoothened signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- protein K29-linked ubiquitination
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of gene expression
- progesterone receptor signaling pathway
- negative regulation of extent of heterochromatin assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding
- ubiquitin binding
- ubiquitin-ubiquitin ligase activity