Ppef1 Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in chromatin remodeling; detection of stimulus involved in sensory perception; and regulation of transcription by RNA polymerase II. Predicted to be active in cytosol and nucleus. Is expressed in ear and nervous system. Orthologous to human PPEF1 (protein phosphatase with EF-hand domain 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppef1 |
| Official Name | protein phosphatase with EF hand calcium-binding domain 1 [Source:MGI Symbol;Acc:MGI:1097157] |
| Ensembl ID | ENSMUSG00000062168 |
| Bio databases IDs | |
| Aliases | protein phosphatase with EF hand calcium-binding domain 1 |
| Synonyms | LOC100363004, PP7, PPEF, PPP7C, PPP7CA, protein phosphatase with EF hand calcium-binding domain 1, protein phosphatase with EF-hand domain 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppef1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- EF-hand domain pair
- EFh
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- Calcineurin-like phosphoesterase
- IQ calmodulin-binding motif
- Calmodulin-binding motif
- EF-hand domain
- EF hand
- IQ domain
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppef1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of stimulus involved in sensory perception
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- iron ion binding
- calcium ion binding
- manganese ion binding
- myosin phosphatase activity