OGFOD1 Gene Summary [Human]
Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | OGFOD1 |
| Official Name | 2-oxoglutarate and iron dependent oxygenase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25585] |
| Ensembl ID | ENSG00000087263 |
| Bio databases IDs | |
| Aliases | 2-oxoglutarate and iron dependent oxygenase domain containing 1, TPA1, termination and polyadenylation 1, homolog (S. cerevisiae) |
| Synonyms | 2-oxoglutarate and iron-dependent oxygenase domain containing 1, 4930415J21Rik, mKIAA1612, RGD1308848, TPA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OGFOD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OGFOD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- stress granule assembly
- regulation of translational termination
- peptidyl-proline hydroxylation
- protein hydroxylation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- protein binding
- iron ion binding
- peptidyl-proline dioxygenase activity
- peptidyl-proline 3-dioxygenase activity