USP10 Gene Summary [Human]
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | USP10 |
| Official Name | ubiquitin specific peptidase 10 [Source:HGNC Symbol;Acc:HGNC:12608] |
| Ensembl ID | ENSG00000103194 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 10 |
| Synonyms | 2610014N07RIK, mKIAA0190, Similar to ubiquitin C-terminal hydrolase-related polypeptide, Ubiquitin carboxyl-terminal hydrolase 10, ubiquitin specific peptidase 10, UBPO, UCHRP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- peptidase
- Ubiquitin carboxyl-terminal hydrolase
- ion channel binding
- ubiquitin-specific protease
- p53 binding
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- organismal death
- ocular sarcoidosis
- osteosarcoma
- osteosarcomagenesis
- breast cancer
- type I enteropathy-associated T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- expression in
- phosphorylation in
- proliferation
- production in
- migration
- activation in
- growth
- invasiveness
- apoptosis
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- monoubiquitinated protein deubiquitination
- rescue of stalled ribosome
- autophagy
- proteolysis
- regulation of autophagy
- cellular response to interleukin-1
- DNA damage response, signal transduction by p53 class mediator
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- cytosolic ribosome
- intermediate filament cytoskeleton
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- p53 binding
- protein binding
- RNA binding
- cysteine-type endopeptidase activity
- ion channel binding