RTRAF Gene Summary [Human]
Enables RNA binding activity; RNA polymerase II complex binding activity; and identical protein binding activity. Involved in negative regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; and tRNA splicing, via endonucleolytic cleavage and ligation. Located in microtubule cytoskeleton; nucleoplasm; and perinuclear region of cytoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RTRAF |
| Official Name | RNA transcription, translation and transport factor [Source:HGNC Symbol;Acc:HGNC:23169] |
| Ensembl ID | ENSG00000087302 |
| Bio databases IDs | |
| Aliases | RNA transcription, translation and transport factor, RLL motif containing 1 |
| Synonyms | 2700060E02Rik, C14orf166, CGI-99, CLE, CLE7, hCLE, hCLE1, LCRP369, Loc68045, LRRGT00192, RGD1304704, RLLM1, RNA transcription, translation and transport factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RTRAF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA transcription, translation and transport factor protein
- enzyme binding
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RTRAF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA splicing, via endonucleolytic cleavage and ligation
- RNA transport
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- mitotic spindle
- cytoplasm
- cytosol
- nucleoplasm
- tRNA-splicing ligase complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- RNA polymerase II core binding