G3BP2 Gene Summary [Human]
Enables RNA binding activity. Involved in positive regulation of stress granule assembly and protein homooligomerization. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | G3BP2 |
| Official Name | G3BP stress granule assembly factor 2 [Source:HGNC Symbol;Acc:HGNC:30291] |
| Ensembl ID | ENSG00000138757 |
| Bio databases IDs | |
| Aliases | G3BP stress granule assembly factor 2, Ras-GTPase activating protein SH3 domain-binding protein 2 |
| Synonyms | E430034L04Rik, G3BP, G3BP stress granule assembly factor 2, GTPASE ACTIVATING FACTOR2, mKIAA0660, RGD1309571 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human G3BP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- NXT1 binding domain
- RNA recognition motif
- protein binding activity, bridging
- enzyme
- protein binding
- PXXP motif
- NTF2_like
- acidic domain
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- organismal death
- lung metastasis
- severe acute respiratory syndrome
role in cell
- expression in
- proliferation
- quantity
- migration
- formation
- replication in
- formation in
- assembly
- invasion by
- fitness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human G3BP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- cytoplasmic sequestering of NF-kappaB
- innate immune response
- protein homooligomerization
- Ras protein signal transduction
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding
- receptor signaling complex scaffold activity