FUS Gene Summary [Human]
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | FUS |
| Official Name | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] |
| Ensembl ID | ENSG00000089280 |
| Bio databases IDs | |
| Aliases | FUS RNA binding protein, heterogeneous nuclear ribonucleoprotein P2, translocated in liposarcoma |
| Synonyms | ALS6, D430004D17Rik, D930039C12Rik, ETM4, FUS1, fused in sarcoma, Fusion, FUS RNA binding protein, HNRNPP2, Pigpen, POMP75, TLS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- RNA recognition motif (RRM) superfamily
- transcription regulator
- transcription co-activator
- low complexity domain
- RNA recognition motif
- RGG2 domain
- protein binding activity, bridging
- transcription activation domain
- chromatin binding
- estrogen receptor binding
- protein binding
- thyroid hormone receptor binding
- ionotropic glutamate receptor binding
- identical protein binding
- G/S Y G/S triplet repeat
- RNA binding
- myosin binding
- mRNA 3' UTR binding
- Zn-finger in Ran binding protein and others
- retinoid X receptor binding
- zinc finger domain
- prion-like domain
Pathways
Biological processes and signaling networks where the FUS gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- metastasis
- digestive system cancer
- abdominal cancer
- tumorigenesis
- motor dysfunction
- respiratory insufficiency
role in cell
- activation in
- interaction in
- binding in
- activity
- expression in
- formation
- formation in
- apoptosis
- proliferation
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- perinuclear region
- granules
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- dendritic spines
- dendritic spine head
- synaptosomes
- synapse
- stress granule
- cellular protrusions
- chromatin
- perikaryon
- dendrites
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- mRNA stabilization
- protein homooligomerization
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular non-membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- RNA binding
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- chromatin binding
- mRNA 3'-UTR binding