SMARCC1 Gene Summary [Human]
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SMARCC1 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [Source:HGNC Symbol;Acc:HGNC:11104] |
| Ensembl ID | ENSG00000173473 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 |
| Synonyms | BAF150, BAF155, CRACC1, HYC5, LOC686453, msp3, Rsc8, SRG3, SWI3, SWI/SNF related BAF chromatin remodeling complex subunit C1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMARCC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline/glutamine rich region
- transcription regulator
- SWIRM-associated domain at the N-terminal
- SWIRM-associated region 1
- SWIRM-associated domain at the C-terminal
- Myb-like DNA-binding domain
- Myb-like domain
- SWIRM domain
- leucine zipper domain
- chromatin binding
- protein binding
- acidic domain
Pathways
Biological processes and signaling networks where the SMARCC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- tumorigenesis
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- susceptibility to congenital hydrocephalus type 5 with aqueductal stenosis
- congenital hydrocephalus
- hereditary disorder
- organismal death
- metastasis
- prostate cancer
role in cell
- expression in
- apoptosis
- proliferation
- accumulation in
- stabilization in
- survival
- invasion by
- migration
- cell cycle progression
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- intracellular space
- nucleoplasm
- sex chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMARCC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- insulin receptor signaling pathway
- positive regulation of cell proliferation
- nervous system development
- positive regulation of myoblast differentiation
- positive regulation of cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- chromatin remodeling
- negative regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- prostate gland development
- regulation of G0 to G1 transition
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- brahma complex
- kinetochore
- chromatin
- male germ cell nucleus
- nucleoplasm
- XY body
- nucleus
- cytoplasm
- npBAF complex
- nuclear matrix
- macromolecular complex
- nBAF complex
- RSC complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- histone binding
- nucleosomal DNA binding