FETUB Gene Summary [Human]

The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
FETUB
Official Name
fetuin B [Source:HGNC Symbol;Acc:HGNC:3658]
Ensembl ID
ENSG00000090512
Bio databases IDs NCBI: 26998 Ensembl: ENSG00000090512
Aliases fetuin B
Synonyms 16G2, 2310011O17Rik, D17980, FET, FETUIN, fetuin B, fetuin beta, fetuin β, Gugu, IRL685, Pp63
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FETUB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • CY
  • protein binding
  • metalloendopeptidase inhibitor

Pathways

Biological processes and signaling networks where the FETUB gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • keratocystic odontogenic tumor
  • keratocystic odontogenic tumors
  • hepatitis B virus-related hepatocellular carcinoma
  • liver cancer
  • epithelial cancer
  • hepatocellular carcinoma
  • aortic valve calcification
regulated by
  • TGFB1
  • cholecalciferol
  • heavy metal
  • methapyrilene
  • nitrofurantoin
  • TNFRSF11B
  • FXR/RXRα/FXR ligand/retinoic acid
  • IRF2BP2
  • PAX5-ELN
  • FOS
regulates
  • endopeptidase
role in cell
  • abnormal morphology
  • binding
  • cell death

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human FETUB gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • binding of sperm to zona pellucida
  • negative regulation of endopeptidase activity
  • single fertilization

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • cysteine-type endopeptidase inhibitor activity
  • metalloendopeptidase inhibitor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.