RBX1 Gene Summary [Human]
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
Details
| Type | Retained Intron |
| Official Symbol | RBX1 |
| Official Name | ring-box 1 [Source:HGNC Symbol;Acc:HGNC:9928] |
| Ensembl ID | ENSG00000100387 |
| Bio databases IDs | |
| Aliases | ring-box 1, regulator of cullins 1 |
| Synonyms | 1500002P15Rik, BA554C12.1, LOC100363742, ring-box 1, RNF75, ROC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- NEDD8 ligase
- ubiquitin protein ligase activity
- transcription factor binding
- enzyme
- protein binding
- eukaryotic initiation factor 4E binding
- binding protein
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- ubiquitin-like-protein ligase
- RING-H2 zinc finger domain
- Anaphase-promoting complex subunit 11 RING-H2 finger
Pathways
Biological processes and signaling networks where the RBX1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- insomnia
- HER2 negative hormone receptor negative breast cancer
- neuroticism
- ductal breast carcinoma
- ductal breast cancer
- organismal death
- complete testicular feminization syndrome
- inflammatory swelling
- depressive disorder
role in cell
- expression in
- apoptosis
- activation in
- molecular cleavage in
- degradation in
- proliferation
- growth
- activation
- accumulation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- spindle pole
- germinal vesicles
- mitotic spindle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of type I interferon production
- protein K48-linked ubiquitination
- regulation of cellular response to insulin stimulus
- spermatogenesis
- protein polyubiquitination
- T cell activation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein neddylation
- positive regulation of protein catabolic process
- response to DNA damage stimulus
- protein monoubiquitination
- post-translational protein modification
- ubiquitin-dependent protein catabolic process
- negative regulation of canonical Wnt receptor signaling pathway
- MAPK cascade
- cellular response to amino acid stimulus
- proteasomal ubiquitin-dependent protein catabolic process
- cellular response to UV
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cullin-RING ubiquitin ligase complex
- nucleoplasm
- nucleus
- cytoplasm
- Cul4A-RING ubiquitin ligase complex
- cytosol
- Cul4B-RING ubiquitin ligase complex
- SCF ubiquitin ligase complex
- Cul2-RING ubiquitin ligase complex
- Cul3-RING ubiquitin ligase complex
- Cul5-RING ubiquitin ligase complex
- Cul7-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- ubiquitin protein ligase binding
- ubiquitin-ubiquitin ligase activity
- NEDD8 ligase activity
- binding, bridging