Fetub Gene Summary [Mouse]
Enables metalloendopeptidase inhibitor activity. Involved in binding activity of sperm to zona pellucida and negative regulation of endopeptidase activity. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including genitourinary system; jaw bone; liver; muscle tissue; and olfactory epithelium. Orthologous to human FETUB (fetuin B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fetub |
| Official Name | fetuin beta [Source:MGI Symbol;Acc:MGI:1890221] |
| Ensembl ID | ENSMUSG00000022871 |
| Bio databases IDs | |
| Aliases | fetuin beta |
| Synonyms | 16G2, 2310011O17Rik, D17980, FET, FETUIN, fetuin B, fetuin beta, fetuin β, Gugu, IRL685, Pp63 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fetub often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- protein binding
- metalloendopeptidase inhibitor
Pathways
Biological processes and signaling networks where the Fetub gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- aortic valve calcification
regulates
- endopeptidase
role in cell
- abnormal morphology
- binding
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fetub gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- negative regulation of endopeptidase activity
- single fertilization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase inhibitor activity
- metalloendopeptidase inhibitor activity