TOP1 Gene Summary [Human]
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TOP1 |
| Official Name | DNA topoisomerase I [Source:HGNC Symbol;Acc:HGNC:11986] |
| Ensembl ID | ENSG00000198900 |
| Bio databases IDs | |
| Aliases | DNA topoisomerase I, Scl-70 antigen |
| Synonyms | Ab2-086, D130064I21RIK, DNA topoisomerase I, DNA topoisomerase type I, Scl70, TOPI, TOPO-1, topoisomerase 1, topoisomerase (DNA) I, Topoisomerase i |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA topoisomerase type I
- core domain, structural
- protein serine/threonine kinase
- nucleic acid binding
- ATP binding
- DNA bending protein
- chromatin binding
- linker domain
- protein domain specific binding
- enzyme
- Eukaryotic DNA topoisomerase I, catalytic core
- C-terminal topoisomerase domain
- protein binding
- sequence-specific DNA binding
- core domain, functional
- DNA binding
- DNA breaking-rejoining enzymes, C-terminal catalytic domain
- Eukaryotic DNA topoisomerase I, DNA binding fragment
- binding protein
- DNA Topoisomerase I (eukaryota)
- single-stranded DNA binding
- double-stranded DNA binding
- Topoisomer_IB_N
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- metastatic non-small cell lung cancer
- lung carcinoma
- gastric cancer
- malignant neoplasm
- liver cancer
- psoriasis
- cancer
- neoplasia
- bile duct cancer
role in cell
- expression in
- activation in
- production in
- growth
- transcription in
- number
- cell viability
- outgrowth
- phosphorylation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- fibrillar center
- cytoplasmic mRNA processing body
- Cytoplasm
- nucleolar region
- dense fibrillar component
- chromosome
- nucleoplasm
- nucleolus derived foci
- nucleoli
- extranucleolar nucleoplasm
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic cleavage
- circadian regulation of gene expression
- chromatin remodeling
- DNA replication
- chromosome segregation
- phosphorylation
- response to xenobiotic stimulus
- DNA topological change
- circadian rhythm
- peptidyl-serine phosphorylation
- programmed cell death
Cellular Component
Where in the cell the gene product is active
- nucleus
- protein-DNA complex
- nuclear chromosome
- cytoplasmic mRNA processing body
- nucleolus
- perikaryon
- fibrillar center
- nucleoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- DNA binding, bending
- chromatin binding
- protein serine/threonine kinase activity
- single-stranded DNA binding
- supercoiled DNA binding
- ATP binding
- DNA binding
- protein binding
- RNA binding
- DNA topoisomerase type I activity