CDH5 Gene Summary [Human]
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | CDH5 |
| Official Name | cadherin 5 [Source:HGNC Symbol;Acc:HGNC:1764] |
| Ensembl ID | ENSG00000179776 |
| Bio databases IDs | |
| Aliases | cadherin 5, VE-cadherin |
| Synonyms | 7B4, AA408225, cadherin 5, CD144, Vec, VE-Cad, Ve Cad2, VE-CADHERIN, VECD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDH5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding domain
- extracellular domain
- protein kinase binding
- beta-catenin binding
- cell adhesion molecule binding
- protein phosphatase binding
- ectodomain
- RGD motif
- protein binding
- receptor binding
- vascular endothelial growth factor receptor binding
- p120-catenin binding domain
- Cadherin, Y-type LIR-motif
- binding protein
- cytoplasmic domain
- receptor signaling complex scaffold protein
- transmembrane domain
- Cadherin repeat-like domain
- ion channel binding
- catenin binding domain
- cytosolic tail domain
- membrane-proximal domain
- extracellular cadherin structural domain
Pathways
Biological processes and signaling networks where the CDH5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- growth failure
- Alzheimer disease
- edema
- arterial aneurysm and dissection
- Klinefelter syndrome
- preeclampsia
- vascular leak syndrome
- diffuse systemic sclerosis
role in cell
- expression in
- apoptosis
- binding
- proliferation
- survival
- quantity
- differentiation
- paracellular permeability
- organization
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- zipper-like junction
- button-like junction
- apical ectoplasmic specialization
- cell junction
- Cytoplasm
- cell surface
- cell borders
- cell periphery
- cellular membrane
- intercellular junctions
- desmosomes
- hemidesmosomes
- endothelial paracellular clefts
- cell-cell contacts
- cytoplasmic bridges
- plasma membrane extracellular face
- nucleoplasm
- nuclear envelope
- sperm head
- pedicels
- anchoring junction
- tight junctions
- cell-cell adherens junctions
- plasma
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDH5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adherens junction organization
- multicellular organismal development
- negative regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- homophilic cell adhesion
- positive regulation of angiogenesis
- negative regulation of endothelial cell apoptotic process
- cell migration
- positive regulation of protein complex assembly
- maintenance of blood-brain barrier
- negative regulation of microtubule polymerization
- regulation of establishment of cell polarity
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- cell morphogenesis
- negative regulation of inflammatory response
- regulation of vascular permeability
- blood vessel endothelial cell migration
- cellular calcium ion homeostasis
- positive regulation of BMP signaling pathway
- regulation of protein phosphorylation
- positive regulation of gene expression
- blood vessel maturation
- cell-cell adhesion mediated by cadherin
- tight junction assembly
- positive regulation of protein dephosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- tight junction
- nuclear membrane
- adherens junction
- cell-cell junction
- membrane
- external side of plasma membrane
- cell junction
- catenin complex
- plasma membrane
- nucleoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- protein binding
- fibrinogen binding
- vascular endothelial growth factor receptor 2 binding
- cadherin binding
- calcium ion binding
- beta-catenin binding
- receptor binding
- ion channel binding
- BMP receptor binding