BRPF3 Gene Summary [Human]
Predicted to enable histone binding activity. Involved in histone H3-K14 acetylation and positive regulation of DNA replication. Part of MOZ/MORF histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | BRPF3 |
| Official Name | bromodomain and PHD finger containing 3 [Source:HGNC Symbol;Acc:HGNC:14256] |
| Ensembl ID | ENSG00000096070 |
| Bio databases IDs | |
| Aliases | bromodomain and PHD finger containing 3 |
| Synonyms | AW493400, bromodomain and PHD finger containing 3, bromodomain and PHD finger containing, 3, mKIAA1286 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRPF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone acetyltransferase
- Enhancer of polycomb-like
- PHD-like zinc-binding domain
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- PHD finger superfamily
- enzyme
- protein binding
- Bromodomain
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRPF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of developmental process
- regulation of transcription, DNA-dependent
- positive regulation of DNA replication
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- MOZ/MORF histone acetyltransferase complex
- cytosol
- extracellular region
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)