ACTR3

ACTR3 Gene Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Details

Type
Protein Coding
Official Symbol
ACTR3
Official Name
actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170]
Ensembl ID
ENSG00000115091
Bio databases IDs NCBI: 10096 Ensembl: ENSG00000115091
Aliases actin related protein 3
Synonyms
1200003A09Rik,actin related protein 3,ARP3,ARP3 actin-related protein 3
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • actin filament binding
  • ATPase binding
  • structural constituent of cytoskeleton
  • Actin
  • actin binding
  • protein binding
  • ASKHA_ATPase-like

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • SNCA
  • UBE3A
  • ACTR2
  • EZH2
  • ARPC1A
  • ARPC2
  • ARPC5
  • ARPC4
  • ARPC3
  • XPO1
disease
  • scleroderma
  • chronic sinusitis
  • non-small cell lung cancer
  • infection by murine hepatitis virus
  • infection by HIV-1
regulated by
  • fluoride
  • tretinoin
  • PTPN11
  • VANGL2
  • HGF
  • perfluorooctane sulfonic acid
  • CAMSAP2
  • 3,5-dihydroxyphenylglycine
  • PRR11
  • Yersinia pestis
regulates
  • F Actin
  • actin
  • ACTIN
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II
  • NPC1L1
  • MYO5B
  • SLC2A4
  • zymosan
role in cell
  • number
  • binding in
  • formation
  • migration
  • assembly
  • extension
  • localization
  • differentiation
  • polymerization
  • morphogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • apical ectoplasmic specialization
  • basal ectoplasmic specialization
  • glutaminergic synapse
  • ruffle
  • Cytoplasm
  • invadopodia
  • cilia
  • cell periphery
  • perinuclear region
  • postsynaptic region
  • podosomes
  • actin cytoskeleton
  • Nucleus
  • actin filaments
  • intercellular junctions
  • hemidesmosomes
  • cytosol
  • membrane ruffles
  • Golgi membrane
  • nucleoli
  • sperm head
  • actin tails
  • membrane rafts
  • brush border
  • pseudopodia
  • cell membrane leading edge
  • excitatory synapses
  • exosomes
  • phagosomes
  • lamellipodia

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ACTR3 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • spindle localization
  • positive regulation of lamellipodium assembly
  • cilium morphogenesis
  • establishment or maintenance of cell polarity
  • Arp2/3 complex-mediated actin nucleation
  • actin polymerization-dependent cell motility
  • asymmetric cell division
  • cellular response to interferon-gamma
  • meiotic chromosome movement towards spindle pole
  • positive regulation of transcription from RNA polymerase II promoter
  • cytokinesis after meiosis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • site of double-strand break
  • Arp2/3 protein complex
  • nucleus
  • cell-cell junction
  • extracellular vesicular exosome
  • focal adhesion
  • brush border
  • cytoplasm
  • membrane
  • actin cytoskeleton
  • cytosol
  • lamellipodium

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • actin filament binding
  • ATP binding
  • protein binding
  • structural constituent of cytoskeleton

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.