WEE1 Gene Summary [Human]
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | WEE1 |
| Official Name | WEE1 G2 checkpoint kinase [Source:HGNC Symbol;Acc:HGNC:12761] |
| Ensembl ID | ENSG00000166483 |
| Bio databases IDs | |
| Aliases | WEE1 G2 checkpoint kinase |
| Synonyms | WEE1A, Wee1b, WEE1 G2 checkpoint kinase, WEE 1 homolog 1 (S. pombe), WEE1hu, WEE1-LIKE protein KINASE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WEE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Rxl motif
- proline rich domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the WEE1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- neoplasia
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- hepatitis B virus-related hepatocellular carcinoma
- endometriosis
- aortic valve calcification
- HER2 negative hormone receptor negative breast cancer
- organismal death
- squamous-cell carcinoma
role in cell
- apoptosis
- growth
- replication in
- cell viability
- phosphorylation in
- activation in
- G2/M phase
- mitosis
- accumulation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal compartment
- perinuclear region
- Plasma Membrane
- nucleoplasm
- nucleoli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WEE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- neuron projection morphogenesis
- establishment of cell polarity
- negative regulation of G1/S transition of mitotic cell cycle
- positive regulation of DNA replication
- microtubule cytoskeleton organization
- protein phosphorylation
- negative regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity