Brpf3 Gene Summary [Mouse]
Predicted to enable zinc ion binding activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in positive regulation of DNA replication and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; sensory organ; and skeleton. Orthologous to human BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brpf3 |
| Official Name | bromodomain and PHD finger containing, 3 [Source:MGI Symbol;Acc:MGI:2146836] |
| Ensembl ID | ENSMUSG00000063952 |
| Bio databases IDs | |
| Aliases | bromodomain and PHD finger containing, 3 |
| Synonyms | AW493400, bromodomain and PHD finger containing 3, bromodomain and PHD finger containing, 3, mKIAA1286 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brpf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone acetyltransferase
- Enhancer of polycomb-like
- PHD-like zinc-binding domain
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- PHD finger superfamily
- enzyme
- protein binding
- Bromodomain
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brpf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of developmental process
- regulation of transcription, DNA-dependent
- positive regulation of DNA replication
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- MOZ/MORF histone acetyltransferase complex
- cytosol
- extracellular region
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)