FBXL19 Gene Summary [Human]
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | FBXL19 |
| Official Name | F-box and leucine rich repeat protein 19 [Source:HGNC Symbol;Acc:HGNC:25300] |
| Ensembl ID | ENSG00000099364 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 19, jumonji C domain-containing histone demethylase 1C |
| Synonyms | 6030430O11, CXXC11, Fbl19, F-box and leucine-rich repeat protein 19, JHDM1C, LOC102554987 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- unmethylated CpG binding
- F-box domain
- F-box domain superfamily
- zinc ion binding
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- protein binding activity, bridging
- PHD finger superfamily
- enzyme
- protein binding
- Leucine Rich repeats (2 copies)
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- chromatin remodeling
- protein demethylation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- transcription cofactor activity
- protein binding
- unmethylated CpG binding
- histone demethylase activity