PITRM1 Gene Summary [Human]
The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]
Details
| Type | Processed Transcript |
| Official Symbol | PITRM1 |
| Official Name | pitrilysin metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:17663] |
| Ensembl ID | ENSG00000107959 |
| Bio databases IDs | |
| Aliases | pitrilysin metallopeptidase 1, PreP peptidasome, presequence protease, mitochondrial |
| Synonyms | 2310012C15Rik, mKIAA1104, MP-1, Ntup1, pitrilysin metallepetidase 1, pitrilysin metallopeptidase 1, PreP, SCAR30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PITRM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- Peptidase M16C associated
- zinc ion binding
- peptidase
- protein binding
- Peptidase M16 inactive domain
- enzyme activator activity
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the PITRM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PITRM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- proteolysis
- protein processing
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- enzyme activator activity
- metalloendopeptidase activity
- metallopeptidase activity