IL1RL1
IL1RL1 Gene Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL1RL1 |
| Official Name | interleukin 1 receptor like 1 [Source:HGNC Symbol;Acc:HGNC:5998] |
| Ensembl ID | ENSG00000115602 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor like 1, homolog of mouse growth stimulation-expressed |
| Synonyms | DER4,FIT-1,IL33R,Il33ra,interleukin 1 receptor-like 1,LY84,Lymphocyte Antigen 84,ST2,ST2L,St2-rs1,ST2V,T1,T1/ST2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytokine binding
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- intracellular domain
- protein binding
- TIR domain
- cytokine receptor
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the IL1RL1 gene plays a role, providing insight into its function and relevance in health or disease.
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Serotonin Receptor Signaling
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Toll-like Receptor Signaling
- TREM1 Signaling
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TIRAP
- IL1RAP
- APP
- IL33
- MAP3K8
- GORASP1
- CREB3L1
- IRAK4
- TSPAN18
- MYD88
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- chronic obstructive pulmonary disease
- asthma
- mechanical hyperalgesia
- pain
- ovarian cancer
- breast cancer
regulated by
- lipopolysaccharide
- IL6
- IL1B
- TNF
- Ca2+
- PKD1
- OVALBUMIN
- TGFB1
- CG
- TCF12
regulates
- PTGS2
- IL4
- p38 MAPK
- TNF
- ERK1/2
- IL1B
- IL6
- IL12 (family)
- MAPK8
- CXCL10
role in cell
- proliferation
- expression in
- activation
- accumulation in
- number
- recruitment
- cellular infiltration by
- phosphorylation in
- activation in
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- focal adhesions
- Golgi Apparatus
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL1RL1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- signal transduction
- positive regulation of inflammatory response
- positive regulation of macrophage activation
- negative regulation of T-helper 1 type immune response
- negative regulation of interferon-gamma production
- positive regulation of chemokine production
- macrophage differentiation
- positive regulation of interleukin-5 production
CELLULAR COMPONENT
Where in the cell the gene product is active
- focal adhesion
- external side of plasma membrane
- cytosol
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- interleukin-33 receptor activity
- NAD+ nucleosidase activity
- protein binding
- interleukin-1 receptor activity
- cytokine receptor activity
- interleukin-33 binding