NAMPT Gene Summary [Human]
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | NAMPT |
| Official Name | nicotinamide phosphoribosyltransferase [Source:HGNC Symbol;Acc:HGNC:30092] |
| Ensembl ID | ENSG00000105835 |
| Bio databases IDs | |
| Aliases | nicotinamide phosphoribosyltransferase, visfatin |
| Synonyms | 1110035O14Rik, AI480535, eNAMPT, iNAMPT, NAmPRTase, nicotinamide phosphoribosyltransferase, PBEF, PBEF1, Pre-B-Cell Colony Enhancing Eactor, PRE-B-CELL COLONY-ENHANCING FACTOR, PRE-B-CELL COLONY-ENHANCING FACTOR 1, VF, VISFATIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NAMPT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- Nicotinate phosphoribosyltransferase (NAPRTase) family
- binding protein
- TIM-like beta/alpha barrel domains
- Nicotinamide phosphoribosyltransferase, N-terminal domain
- nicotinamide phosphoribosyltransferase
- protein binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the NAMPT gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- neoplasia
- breast cancer
- hepatitis
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- psoriasis
- rheumatoid arthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- cell death
- apoptosis
- cell viability
- cytotoxicity
- proliferation
- expression in
- phosphorylation in
- survival
- activation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- mitochondrial fraction
- cell junction
- Cytoplasm
- Nucleus
- cytosol
- mitochondrial matrix
- nuclear speckles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NAMPT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- circadian regulation of gene expression
- positive regulation of nitric-oxide synthase biosynthetic process
- signal transduction
- insulin receptor signaling pathway
- positive regulation of cell proliferation
- NAD biosynthetic process
- cell-cell signaling
- NAD biosynthesis via nicotinamide riboside salvage pathway
- positive regulation of transcription from RNA polymerase II promoter
- adipose tissue development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- nuclear speck
- cytosol
- cell junction
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cytokine activity
- nicotinamide phosphoribosyltransferase activity