PIK3IP1 Gene Summary [Human]
Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in negative regulation of phosphatidylinositol 3-kinase activity and negative regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PIK3IP1 |
| Official Name | phosphoinositide-3-kinase interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24942] |
| Ensembl ID | ENSG00000100100 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase interacting protein 1, transmembrane inhibitor of PI3K |
| Synonyms | 1500004A08RIK, 5830455E04Rik, Crkd, HGFL, hHGFL(S), MGC17330, phosphoinositide-3-kinase interacting protein 1, RGD1311203, TrIP, zgc:66482 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIK3IP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- KR
- phosphoinositide 3-kinase regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- liver cancer
- tumorigenesis
- non-small cell lung carcinoma
- non-small cell lung cancer
- peripheral arterial disease
- latent tuberculosis
- infection by Listeria monocytogenes
role in cell
- growth
- phosphorylation in
- production in
- activation
- proliferation
- cell viability
- apoptosis
- synthesis in
- degradation in
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIK3IP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- receptor binding