FOXO3 Gene Summary [Human]
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXO3 |
| Official Name | forkhead box O3 [Source:HGNC Symbol;Acc:HGNC:3821] |
| Ensembl ID | ENSG00000118689 |
| Bio databases IDs | |
| Aliases | forkhead box O3 |
| Synonyms | 1110048B16RIK, 2010203A17RIK, AF6q21, Fkhr2, FKHRL1, FKHRL1P2, forkhead box O3, FOXO2, FOXO3A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- transcription activation domain
- transcription factor binding
- chromatin binding
- Forkhead domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Caspase 3 cleavage site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Akt phosphorylation site
- protein kinase binding
- nuclear export signal
- DNA binding domain
- beta-catenin binding
- nucleic acid binding
- Transactivation domain of FOXO protein family
- CR2 domain
- CR3 domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- FORKHEAD
- phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- KIX-binding domain of forkhead box O, CR2
- transcription factor activity
Pathways
Biological processes and signaling networks where the FOXO3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Autophagy
- Cancer Drug Resistance By Drug Efflux
- Chronic Myeloid Leukemia Signaling
- Endometrial Cancer Signaling
- ERK5 Signaling
- Erythropoietin Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IGF-1 Signaling
- IL-7 Signaling Pathway
- Insulin Receptor Signaling
- Non-Small Cell Lung Cancer Signaling
- Osteoarthritis Pathway
- PI3K Signaling in B Lymphocytes
- PTEN Signaling
- Serotonin Receptor Signaling
- Sirtuin Signaling Pathway
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- tumorigenesis
- neoplasia
- malaria
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- non-small cell lung cancer
- acute lymphoblastic leukemia
role in cell
- phosphorylation in
- expression in
- cell viability
- activation in
- production in
- invasion by
- function in
- migration
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- cell cortex
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial outer membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to starvation
- negative regulation of neuron differentiation
- brain morphogenesis
- response to xenobiotic stimulus
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of erythrocyte differentiation
- neuronal stem cell maintenance
- positive regulation of neuron apoptotic process
- positive regulation of regulatory T cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- ovulation from ovarian follicle
- regulation of translation
- initiation of primordial ovarian follicle growth
- antral ovarian follicle growth
- positive regulation of transcription, DNA-dependent
- cellular response to glucose stimulus
- positive regulation of muscle atrophy
- canonical Wnt receptor signaling pathway
- response to fatty acid
- positive regulation of endothelial cell apoptotic process
- regulation of neural precursor cell proliferation
- cellular response to hypoxia
- transcription from mitochondrial promoter
- cellular response to glucose starvation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of autophagy
- tumor necrosis factor-mediated signaling pathway
- oocyte maturation
- cellular response to corticosterone stimulus
- positive regulation of apoptotic process
- DNA damage response, signal transduction by p53 class mediator
- cellular response to oxidative stress
- negative regulation of cell migration
- response to dexamethasone stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
- macromolecular complex
- mitochondrial outer membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- chromatin DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription cofactor binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- mitochondrial RNA polymerase binding promoter specificity activity