SATB1 Gene Summary [Human]
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]
Details
| Type | Protein Coding |
| Official Symbol | SATB1 |
| Official Name | SATB homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10541] |
| Ensembl ID | ENSG00000182568 |
| Bio databases IDs | |
| Aliases | SATB homeobox 1 |
| Synonyms | 2610306G12Rik, DEFDA, DHDBV, KTZSL, SATB homeobox 1, special AT-rich sequence binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SATB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LXXLL motif
- dimerization domain
- CUT1-like DNA-binding domain of SATB
- DNA binding domain
- N-terminal domain of SATB1 and similar proteins
- PDZ-like domain
- nucleic acid binding
- CR2 domain
- transcription factor binding
- chromatin binding
- protein binding
- MAR binding domain
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- CUT domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- homeodomain
- transcription factor activity
- nuclear matrix targeting site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- breast carcinoma
- developmental delay with dysmorphic facies and dental anomalies
- Kohlschutter-Tonz syndrome-like
- chronic mucus hypersecretion
- Sjögren syndrome
- habitual abortion
- Sézary syndrome
- Parkinson disease
- lung adenocarcinoma
role in cell
- proliferation
- expression in
- cell death
- activation in
- growth
- apoptosis
- quantity
- number
- migration
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- heterochromatin
- interchromatin space
- nucleoplasm
- nuclear bodies
- nuclear matrix
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SATB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity