TFIP11 Gene Summary [Human]
This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Details
| Type | Protein Coding |
| Official Symbol | TFIP11 |
| Official Name | tuftelin interacting protein 11 [Source:HGNC Symbol;Acc:HGNC:17165] |
| Ensembl ID | ENSG00000100109 |
| Bio databases IDs | |
| Aliases | tuftelin interacting protein 11 |
| Synonyms | 2810002G02Rik, bK445C9.6, NTR1, Spp382, Srr1, STIP, STIP-1, TIP33, TIP39, tuftelin interacting protein 11, Tuftelin interacting protein 33 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFIP11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tuftelin interacting protein N terminal
- G-patch domain
- protein binding
- GC-rich sequence DNA-binding factor-like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- interchromatin granule cluster fractions
- catalytic step 2 spliceosome
- Cytoplasm
- Nucleus
- spliceosomes
- nucleoplasm
- nucleoli
- nuclear speckles
- extracellular matrix
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TFIP11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of double-strand break repair via nonhomologous end joining
- protection from non-homologous end joining at telomere
- spliceosomal complex disassembly
- negative regulation of protein complex assembly
- RNA processing
- negative regulation of protein binding
- biomineral tissue development
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- spliceosomal complex
- extracellular matrix
- nucleolus
- U2-type post-mRNA release spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding