PLK4 Gene Summary [Human]
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | PLK4 |
| Official Name | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] |
| Ensembl ID | ENSG00000142731 |
| Bio databases IDs | |
| Aliases | polo like kinase 4 |
| Synonyms | 1700028H20, AC146980.2, AI385771, MCCRP2, polo-like kinase 4, SAK, STK18 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- POLO box duplicated region
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- POLO_box
- Polo-like Kinase 4 Polo Box 2
- kinase
- Serine/Threonine protein kinases, catalytic domain
- PEST domain
- kinase domain
- Protein Kinases, catalytic domain
- Polo-like Kinase 4 Polo Box 1
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PLK4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- skin barrier defect
- autosomal recessive microcephaly and chorioretinopathy type 2
- metastasis
- chromosomal instability
- organismal death
- alveolar rhabdomyosarcoma
- soft tissue sarcoma cancer
- prostate cancer
role in cell
- phosphorylation in
- proliferation
- apoptosis
- quantity
- growth
- migration
- expression in
- activation in
- replication in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
- perinuclear region
- centrosome
- centriole
- cytosol
- nucleoli
- sex chromatin
- pro-centriole
- cleavage furrow
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- centriole replication
- trophoblast giant cell differentiation
- positive regulation of centriole replication
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- XY body
- nucleus
- centrosome
- cleavage furrow
- centriole
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activity