TOMM22 Gene Summary [Human]
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TOMM22 |
| Official Name | translocase of outer mitochondrial membrane 22 [Source:HGNC Symbol;Acc:HGNC:18002] |
| Ensembl ID | ENSG00000100216 |
| Bio databases IDs | |
| Aliases | translocase of outer mitochondrial membrane 22 |
| Synonyms | 1C9-2, 2310047D01, MST065, MSTP065, rTOM22, TOM22, translocase of outer mitochondrial membrane 22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOMM22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- cytoplasmic domain
- protein binding
- signal sequence binding
- Mitochondrial import receptor subunit TOM22 and similar proteins
- transporter
Pathways
Biological processes and signaling networks where the TOMM22 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by Influenza A virus subtype H1N1
role in cell
- expression in
- binding in
- apoptosis
- transmembrane potential
- synthesis in
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOMM22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein transmembrane transport
- protein import into mitochondrial outer membrane
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- mitochondrial outer membrane
- mitochondrial outer membrane translocase complex
Molecular Function
What the gene product does at the molecular level
- mitochondrion targeting sequence binding
- protein binding
- protein transmembrane transporter activity