GTPBP1 Gene Summary [Human]
This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GTPBP1 |
| Official Name | GTP binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4669] |
| Ensembl ID | ENSG00000100226 |
| Bio databases IDs | |
| Aliases | GTP binding protein 1 |
| Synonyms | GP-1, GTP-binding, GTP binding protein 1, GTPBP, HSPC018, NEDFET1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTPBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- tRNA binding
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- translation elongation factor
- Elongation factor Tu C-terminal domain
- GTPase
- enzyme
- protein binding
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTPBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mRNA catabolic process
- immune response
- signal transduction
- cytoplasmic translation
- GTP metabolic process
- translational elongation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- RNA binding
- protein binding
- translation elongation factor activity
- GTPase activity
- tRNA binding