DNAL4 Gene Summary [Human]

This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]

Details

Type
Protein Coding
Official Symbol
DNAL4
Official Name
dynein axonemal light chain 4 [Source:HGNC Symbol;Acc:HGNC:2955]
Ensembl ID
ENSG00000100246
Bio databases IDs NCBI: 10126 Ensembl: ENSG00000100246
Aliases dynein axonemal light chain 4
Synonyms D15Ertd424e, Dnalc4, dynein axonemal light chain 4, dynein, axonemal, light chain 4, MRMV3, PIG27
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PLN03058
  • Dynein light chain type 1
  • dynein light chain (DLC)-like domain superfamily
  • enzyme
  • protein binding
  • identical protein binding
  • microtubule motor protein

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • mirror movements type 3
regulated by
regulates
  • Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin
role in cell
  • movement
  • movement by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DNAL4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • microtubule-based movement

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • dynein complex
  • cilium
  • plasma membrane
  • microtubule

Molecular Function

What the gene product does at the molecular level
  • microtubule motor activity
  • identical protein binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

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