GNA14 Gene Summary [Human]
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | GNA14 |
| Official Name | G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] |
| Ensembl ID | ENSG00000156049 |
| Bio databases IDs | |
| Aliases | G protein subunit alpha 14 |
| Synonyms | G14alpha, G14α, G Alpha14, G protein alpha 14, G protein subunit alpha 14, G protein subunit α 14, G protein α 14, guanine nucleotide binding protein, alpha 14, guanine nucleotide binding protein, α 14, HG1I, Tieg3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNA14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- G protein alpha subunit
- GTPase
- G-protein alpha subunit
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the GNA14 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- G Protein Signaling Mediated by Tubby
- GABA Receptor Signaling
- Gαi Signaling
- Gαq Signaling
- Huntington's Disease Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- PPARα/RXRα Activation
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Synaptic Long Term Potentiation
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- idiopathic scoliosis
- tufted angioma
- angiomatosis
- pervasive developmental disorder
- diabetic nephropathy
- subarachnoid hemorrhage
- kaposiform hemangioendothelioma
- anastomosing hemangioma
role in cell
- expression in
- phosphorylation in
- apoptosis
- production in
- proliferation
- cell death
- activation in
- formation in
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNA14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- regulation of action potential
- phospholipase C-activating dopamine receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor binding
- protein binding
- metal ion binding
- GTPase activity
- G-protein beta/gamma-subunit complex binding